Anup Ramachandran Selected Research

Acetaminophen (Paracetamol)

5/2022	Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an acetaminophen overdose.
1/2022	The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
1/2022	Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice.
1/2022	Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
12/2021	Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls.
11/2021	Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?
10/2021	Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole.
3/2021	Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
1/2021	Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing.
1/2021	Mitochondrial Dynamics in Drug-Induced Liver Injury.

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Anup Ramachandran Research Topics

Disease

28	Acute Liver Failure (Fulminant Hepatic Failure) 05/2022 - 02/2011
25	Necrosis 01/2022 - 02/2011
19	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 10/2010
7	Fibrosis (Cirrhosis) 11/2016 - 03/2002
5	Poisoning 01/2022 - 07/2011
5	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017 - 11/2005
4	Liver Failure 01/2022 - 12/2012
4	Liver Diseases (Liver Disease) 01/2021 - 06/2014
4	Inflammation (Inflammations) 04/2020 - 01/2012
3	Renal Tubular Acidosis (Distal Renal Tubular Acidosis) 10/2019 - 06/2010
2	Drug-Related Side Effects and Adverse Reactions 12/2019 - 02/2012
2	Hypoxia (Hypoxemia) 01/2018 - 10/2010
2	Pancreatitis 11/2016 - 01/2016
2	Chemical and Drug Induced Liver Injury 05/2013 - 02/2012
2	Renal Insufficiency (Renal Failure) 07/2011 - 06/2006
2	Ascites 02/2007 - 06/2006
1	Iron Overload 01/2022
1	Chronic Pain 01/2021
1	Acute Kidney Injury (Acute Renal Failure) 12/2020
1	Reperfusion Injury 01/2020
1	Rupture 12/2019
1	Pain (Aches) 05/2019
1	Cryptogenic Cirrhosis 01/2018
1	Portal Hypertension 09/2017
1	Thrombotic Microangiopathies 09/2017
1	Type 2 Diabetes Mellitus (MODY) 12/2016
1	Acute-On-Chronic Liver Failure 11/2016
1	Sepsis (Septicemia) 11/2016
1	End Stage Liver Disease 11/2016
1	Exanthema (Rash) 09/2015

Drug/Important Bio-Agent (IBA)

46	Acetaminophen (Paracetamol)FDA LinkGeneric 05/2022 - 10/2010
17	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2006
13	Oxidants (Oxidizing Agents)IBA 03/2021 - 03/2011
7	Oxygen (Dioxygen)IBA 01/2017 - 03/2002
6	Peroxynitrous Acid (Peroxynitrite)IBA 01/2022 - 02/2011
6	Free RadicalsIBA 01/2017 - 03/2002
5	Pharmaceutical PreparationsIBA 12/2021 - 12/2012
5	Glutathione (Reduced Glutathione)IBA 06/2020 - 02/2011
5	Alanine Transaminase (SGPT)IBA 01/2019 - 03/2011
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2017 - 06/2006
5	Thioacetamide (Thioacetamid)IBA 01/2017 - 11/2005
5	Carbon Tetrachloride (Tetrachloromethane)IBA 05/2009 - 11/2005
4	AntidotesIBA 01/2022 - 01/2018
3	Fomepizole (Antizol)FDA LinkGeneric 01/2022 - 01/2019
3	JNK Mitogen-Activated Protein KinasesIBA 03/2021 - 01/2013
3	Acetylcysteine (Siran)FDA LinkGeneric 01/2020 - 01/2018
3	AntioxidantsIBA 01/2019 - 03/2002
3	von Willebrand FactorIBA 09/2017 - 01/2014
3	Metalloproteases (Metalloproteinases)IBA 09/2017 - 01/2014
3	ThrombospondinsIBA 09/2017 - 01/2014
3	DisintegrinsIBA 09/2017 - 01/2014
2	Ethylene Glycol (Monoethylene Glycol)IBA 01/2022 - 01/2019
2	Methanol (Carbinol)IBA 01/2022 - 01/2019
2	Superoxides (Superoxide)IBA 01/2022 - 03/2011
2	Analgesics (Analgesic Drugs)IBA 12/2021 - 08/2020
2	MitogensIBA 03/2021 - 01/2012
2	Phosphotransferases (Kinase)IBA 03/2021 - 01/2012
2	Caspase InhibitorsIBA 08/2020 - 08/2018
2	ChemokinesIBA 04/2020 - 01/2012
2	CytokinesIBA 04/2020 - 01/2012
2	dirhodium tetraacetate (DRTA)IBA 10/2019 - 06/2010
2	Proton Pumps (Proton Pump)IBA 10/2019 - 07/2011
2	Adenosine Triphosphate (ATP)IBA 05/2018 - 07/2011
2	NitratesIBA 01/2018 - 01/2017
2	Apoptosis Inducing FactorIBA 02/2017 - 12/2013
2	3-nitrotyrosineIBA 01/2017 - 02/2011
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 02/2012
2	EnzymesIBA 06/2014 - 05/2009
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 03/2011 - 10/2010
2	Biomarkers (Surrogate Marker)IBA 05/2009 - 06/2006
2	RetinoidsIBA 05/2009 - 11/2005
2	Malondialdehyde (Propanedial)IBA 05/2008 - 02/2007
2	CalciumIBA 06/2006 - 03/2002
1	TransferasesIBA 01/2022
1	Alanine (L-Alanine)FDA Link 01/2022
1	Deferoxamine (Desferal)FDA LinkGeneric 01/2022
1	Minocycline (Cyclops)FDA LinkGeneric 01/2022
1	IronIBA 01/2022
1	AntipyreticsIBA 12/2021
1	CaspasesIBA 08/2020
1	Netrin-1IBA 01/2020
1	EndonucleasesIBA 12/2019
1	Mitogen-Activated Protein KinasesIBA 12/2019
1	Mitochondrial Permeability Transition PoreIBA 12/2019
1	Adenosine Triphosphatases (ATPase)IBA 10/2019
1	Adenosine Diphosphate (ADP)IBA 10/2019
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 01/2019
1	Diclofenac (SR 38)FDA LinkGeneric 05/2018
1	Isoniazid (Ftivazide)FDA LinkGeneric 05/2018
1	Rifampin (Rifampicin)FDA LinkGeneric 05/2018
1	Amiodarone (Amiodarona)FDA LinkGeneric 05/2018
1	Mitochondrial DNA (mtDNA)IBA 10/2017
1	endonuclease GIBA 02/2017
1	Metformin (Glucophage)FDA LinkGeneric 12/2016
1	HydrogenIBA 11/2016
1	AntigensIBA 11/2016
1	Polysaccharides (Glycans)IBA 01/2016
1	CitrullineIBA 01/2016
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2016

Therapy/Procedure

1	Length of Stay 11/2016